Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models Ichimura Y; Komatsu MExp Anim 2011[]; 60 (4): 329-45Autophagy is a cellular degradation system in which cytoplasmic components including organelles are sequestered by double membrane structures called autophagosomes and sequestered materials are degraded by lysosomal hydrolases for supply of amino acids and for cellular homeostasis. The autophagy induced in response to nutrient deprivation is executed in a nonselective fashion, and adaptation to nutrient-poor conditions is the main purpose of autophagy. On the other hand, recent studies have shed light on another indispensable role for starvation-independent or constitutive autophagy in cellular homeostasis, which is mediated by selective degradation of a specific substrate(s). Herein, we introduce pathophysiological roles of starvation-induced, constitutive, and selective autophagy (in particular, selective turnover of p62 through autophagy) disclosed by autophagy-deficient mouse models.|*Autophagy[MESH]|Animals[MESH]|Cell Physiological Phenomena[MESH]|Cytoplasm/metabolism[MESH]|Disease Models, Animal[MESH]|Lysosomes/metabolism[MESH]|Mice[MESH]|Microtubule-Associated Proteins/metabolism[MESH]|Phagosomes/*metabolism[MESH]|Saccharomyces cerevisiae/physiology[MESH]|Signal Transduction[MESH]|Starvation/*physiopathology[MESH]|Transcription Factor TFIIH[MESH]|Transcription Factors/genetics/physiology[MESH] |
