Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21785211&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Oxidized CaMKII: a "heart stopper" for the sinus node?Huke S; Knollmann BCJ Clin Invest 2011[Aug]; 121 (8): 2975-7Each normal heart beat is triggered by an electrical impulse emitted from a group of specialized cardiomyocytes that together form the sinoatrial node (SAN). In this issue of the JCI, Swaminathan and colleagues demonstrate a new molecular mechanism that can disrupt the normal beating of the heart: angiotensin II - typically found in increased levels in heart failure and hypertension - oxidizes and activates Ca2+/calmodulin-dependent kinase II via NADPH oxidase activation, causing SAN cell death. The loss of SAN cells produces an electrical imbalance termed the "source-sink mismatch," which may contribute to the SAN dysfunction that affects millions of people later in life and complicates a number of heart diseases.|Angiotensin II/metabolism[MESH]|Animals[MESH]|Apoptosis[MESH]|Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism[MESH]|Calcium/metabolism[MESH]|Cell Death[MESH]|Electrophysiology/methods[MESH]|Heart Diseases/prevention & control/therapy[MESH]|Heart Failure[MESH]|Humans[MESH]|Mice[MESH]|Models, Biological[MESH]|NADPH Oxidases/metabolism[MESH]|Oxygen/*chemistry[MESH]|Sinoatrial Node/metabolism/*physiology[MESH] |
