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  • Cellular and nerve fibre catecholaminergic thymic network: steroid hormone dependent activity
  • Leposavic G; Pilipovic I; Perisic M
  • Physiol Res 2011[]; 60 Suppl 1 (): S71-82
  • The thymus plays a critical role in establishing and maintaining the peripheral T-cell pool. It does so by providing a microenvironment within which T-cell precursors differentiate and undergo selection processes to create a functional population of major histocompatibility complex-restricted, self-tolerant T cells. These cells are central to adaptive immunity. Thymic T-cell development is influenced by locally produced soluble factors and cell-to-cell interactions, as well as by sympathetic noradrenergic and endocrine system signalling. Thymic lymphoid and non-lymphoid cells have been shown not only to express beta- and alpha(1)- adrenoceptors (ARs), but also to synthesize catecholamines (CAs). Thus, it is suggested that CAs influence T-cell development via both neurocrine/endocrine and autocrine/paracrine action, and that they serve as immunotransmitters between thymocytes and nerves. CAs acting at multiple sites along the thymocyte developmental route affect T-cell generation not only numerically, but also qualitatively. Thymic CA level and synthesis, as well as AR expression exhibit sex steroid-mediated sexual dimorphism. Moreover, the influence of CAs on T-cell development exhibits glucocorticoid-dependent plasticity. This review summarizes recent findings in this field and our current understanding of complex and multifaceted neuroendocrine-immune communications at thymic level.
  • |*Signal Transduction[MESH]
  • |Adrenergic Fibers/*metabolism[MESH]
  • |Animals[MESH]
  • |Catecholamines/*metabolism[MESH]
  • |Cell Communication[MESH]
  • |Female[MESH]
  • |Gonadal Steroid Hormones/*metabolism[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Receptors, Adrenergic/*metabolism[MESH]
  • |Sex Characteristics[MESH]
  • |T-Lymphocytes/immunology/*metabolism[MESH]
  • |Thymus Gland/immunology/*innervation/*metabolism[MESH]

  • *{{pmid21777027}}
    *<b>[ Cellular and nerve fibre catecholaminergic thymic network: steroid hormone dependent activity ]</b> Physiol Res 2011; 60 Suppl 1() ; S71-82 Leposavic G; Pilipovic I; Perisic M


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    Physiol Res

    S71 .60 Suppl 1 2011