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lüll Sulfur dioxide acts as a novel endogenous gaseous signaling molecule in the cardiovascular system Chen SS; Tang CS; Jin HF; DU JBChin Med J (Engl) 2011[Jun]; 124 (12): 1901-5OBJECTIVE: Sulfur dioxide was considered to be toxic and detrimental to human health. However, this review highlights recent advances that suggest sulfur dioxide might be a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions. DATA SOURCES: The data used in this review were mainly from the studies reported in Medline and PubMed published from 1986 to 2010. STUDY SELECTION: Original articles and critical reviews selected were relevant to exogenous and endogenous sulfur dioxide. RESULTS: The sulfur dioxide/aspartate amino transferase pathway is endogenously generated in the cardiovascular system, and sulfur dioxide shows broad bioactive effects, such as antihypertension, vasodilation, and amelioration of vascular remodeling. A disturbed sulfur dioxide/aspartate amino transferase pathway is known to be involved in the pathogenesis of many cardiovascular diseases, such as ischemia-reperfusion injury, monocrotaline-induced pulmonary hypertension, athrosclerosis, spontaneous hypertension and hypoxic pulmonary hypertension. Furthermore, in experimental studies the prognosis of these cardiovascular diseases can be improved by targeting endogenous sulfur dioxide. CONCLUSION: The findings suggest that sulfur dioxide is a novel endogenous gaseous signaling molecule involved in the regulation of cardiovascular functions.|Animals[MESH]|Cardiovascular Diseases/*etiology[MESH]|Humans[MESH]|Hypertension, Pulmonary/etiology[MESH]|Myocardial Reperfusion Injury/etiology[MESH]|Rats[MESH]|Rats, Inbred SHR[MESH]|Signal Transduction/*physiology[MESH]|Sulfur Dioxide/*metabolism[MESH] |