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lüll Regional and mucosal memory T cells Sheridan BS; Lefrancois LNat Immunol 2011[Jun]; 12 (6): 485-91After infection, most antigen-specific memory T cells reside in nonlymphoid tissues. Tissue-specific programming during priming leads to directed migration of T cells to the appropriate tissue, which promotes the development of tissue-resident memory in organs such as intestinal mucosa and skin. Mechanisms that regulate the retention of tissue-resident memory T cells include transforming growth factor-beta (TGF-beta)-mediated induction of the E-cadherin receptor CD103 and downregulation of the chemokine receptor CCR7. These pathways enhance protection in internal organs, such as the nervous system, and in the barrier tissues--the mucosa and skin. Memory T cells that reside at these surfaces provide a first line of defense against subsequent infection, and defining the factors that regulate their development is critical to understanding organ-based immunity.|Animals[MESH]|Antigens, CD/immunology/metabolism[MESH]|Antigens/*immunology[MESH]|Humans[MESH]|Immunologic Memory/*immunology[MESH]|Integrin alpha Chains/immunology/metabolism[MESH]|Models, Immunological[MESH]|Mucous Membrane/*immunology[MESH]|Receptors, CCR7/immunology/metabolism[MESH]|T-Lymphocytes/*immunology/metabolism[MESH]|Transforming Growth Factor beta/immunology/metabolism[MESH] |