Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Advances in the treatment of cutaneous leishmaniasis in the new world in the last ten years: a systematic literature review Almeida OL; Santos JBAn Bras Dermatol 2011[May]; 86 (3): 497-506INTRODUCTION: The therapeutic arsenal against cutaneous leishmaniasis is very limited. Pentavalent antimonial compounds have been the drugs of choice for treatment of this disease for over 50 years. Despite their effectiveness, these drugs require daily injections, have many side effects and present prolonged healing time. OBJECTIVE: To carry out a systematic literature review on the advances in the treatment of cutaneous leishmaniasis in the new world in the last ten years. METHODS: We conducted an electronic search on the Pubmed and LILACS database as well as on the SciELO electronic library in June 2009. The search words in English were: "cutaneous", "leishmaniasis" and "treatment". We included only randomized, double-blind and placebo controlled trials. We used the Jadad scale to assess the quality of the selected studies. RESULTS: According to the inclusion and exclusion criteria, only eight articles were selected. The drugs evaluated in the selected studies were glucantimeA(R), miltefosine, immunotherapy, imiquimod, rhGM-CSF and pentoxifylline, and paromomycin. CONCLUSION: Although cutaneous leishmaniasis is a major public health issue, the published data on the use of new drugs for the treatment of cutaneous leishmaniasis in Brazil are still quite limited.|Aminoquinolines/therapeutic use[MESH]|Antiprotozoal Agents/*therapeutic use[MESH]|Brazil[MESH]|Developing Countries[MESH]|Humans[MESH]|Imiquimod[MESH]|Leishmaniasis, Cutaneous/*drug therapy[MESH]|Meglumine Antimoniate[MESH]|Meglumine/therapeutic use[MESH]|Organometallic Compounds/therapeutic use[MESH]|Paromomycin/therapeutic use[MESH]|Pentoxifylline/therapeutic use[MESH]|Phosphorylcholine/analogs & derivatives/therapeutic use[MESH] |