Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll (177)Lu-Labeled methylene diphosphonate Chopra AMolecular Imaging and Contrast Agent Database (MICAD)-/-ä 2004[]; ä (ä): äMost patients with malignancies of the breast, prostate, lungs, thyroid, or kidneys suffer from severe bone pain due to metastases of the cancer in the skeletal tissue (1, 2). Although several interventions such as analgesics, bisphosphonates, hormone therapy, and systemic radionuclide therapy are available to manage bone pain, these treatments are known to have many undesirable secondary effects on the patient (2). Radiopharmaceuticals containing nuclides such as strontium-89 (as (89)SrCl(2)) and samarium-153 (administered as (153)Sm-labeled ethylenediamine tetramethylene phosphonic acid (EDTMP)), which have been approved by the United States Food and Drug Administration (FDA) for the treatment of bone pain due to metastases, are commonly used for the palliative care of bone pain in cancer patients (2). However, these are not ideal agents to treat bone pain because the radionuclide either has a long half-life and generates high-energy beta(-) particles ((89)Sr has a half-life of ~50 days; E(beta(max)) = 1.49 MeV) or is short-lived and has to be produced in close vicinity to the treatment center ((153)Sm has a half-life of ~47 h; E(beta(max)) = 0.81 MeV; Egamma = 103 keV (28%)) (1). A major limitation of using these bone pain palliative agents is that they produce myelotoxicity in some patients (3). Between the two labeled compounds, (89)SrCl(2) appears to be the agent of choice for clinical applications because its longer half-life allows some flexibility to develop a suitable treatment regimen for the patient. There is great interest in the development of alternative radiolabeled compounds that can be used to treat pain resulting from osseous metastases (2). An important characteristic of a new labeled compound is that it must have the ability to be targeted specifically to the cancerous lesions on the skeleton and should be minimally toxic to the bone marrow as discussed elsewhere (3-5). In a study with healthy rats, it was reported that EDTMP labeled with lutetium-177 ([(177)Lu]-EDTMP) was cleared rapidly from blood circulation, showed little uptake in the soft tissues, and accumulated primarily in the bones of these animals (6). Chakraborty et al. made similar observations when they investigated the biodistribution of [(177)Lu]-EDTMP in rats (7), and a freeze-dried kit for the preparation of this radiopharmaceutical has also been developed (8). On the basis of these observations, there is a renewed interest to use (177)Lu (half-life, ~7 days; E(beta(max)) = 497 keV; Egamma = 113 keV (6.4%); 208 keV (11%)) as an alternative nuclide to those currently in use ((89)Sr and (153)Sm) in the development of a palliative care agent for pain due to the metastases of cancer to the skeletal tissue (4, 5). The main advantages of using (177)Lu are that it can be easily transported to places where it is not available, and the low-energy gamma photons emitted by the nuclide allow detection of the bone lesions with scintigraphy. The International Atomic Energy Agency has initiated projects to develop (177)Lu-labeled compounds as palliative care agents for bone pain (5). Methylene diphosphonate (MDP; also known as methylene diphosphate) labeled with technetium-99m is a commonly used bone-imaging agent approved by the FDA to investigate osteogenesis, and it is commercially available in the form of a kit (9). Because of its easy availability, and on the basis of the information mentioned above, Abbasi developed (177)Lu-labeled MDP ([(177)Lu]-MDP) as a possible alternate radiopharmaceutical for the palliative care of bone pain (10). The biodistribution of this tracer was studied in Sprague-Dawley rats and confirmed with gamma planar imaging.ä |