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lüll Need for a comprehensive medical approach to the neuro-immuno-gastroenterology of irritable bowel syndrome Katiraei P; Bultron GWorld J Gastroenterol 2011[Jun]; 17 (23): 2791-800Irritable bowel syndrome (IBS) is defined by the Rome III criteria as symptoms of recurrent abdominal pain or discomfort with the onset of a marked change in bowel habits with no evidence of an inflammatory, anatomic, metabolic, or neoplastic process. As such, many clinicians regard IBS as a central nervous system problem of altered pain perception. Here, we review the recent literature and discuss the evidence that supports an organic based model, which views IBS as a complex, heterogeneous, inter-dependent, and multi-variable inflammatory process along the neuronal-gut axis. We delineate the organic pathophysiology of IBS, demonstrate the role of inflammation in IBS, review the possible differences between adult and pediatric IBS, discuss the merits of a comprehensive treatment model as taught by the Institute of Functional Medicine, and describe the potential for future research for this syndrome.|*Gastroenterology[MESH]|*Neuroimmunomodulation[MESH]|Abdominal Pain/etiology/physiopathology[MESH]|Antigens/immunology[MESH]|Gastrointestinal Tract/microbiology/physiology/physiopathology[MESH]|Humans[MESH]|Inflammation/physiopathology[MESH]|Irritable Bowel Syndrome/pathology/*physiopathology[MESH]|Serotonin/metabolism[MESH]|Stress, Physiological[MESH] |