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Helicobacter pylori neutrophil activating protein as target for new drugs against H pylori inflammation Choli-Papadopoulou T; Kottakis F; Papadopoulos G; Pendas SWorld J Gastroenterol 2011[Jun]; 17 (21): 2585-91Helicobacter pylori (H. pylori) infection is among the most common human infections and the major risk factor for peptic ulcer disease and gastric cancer. Within this work we present the implication of C-terminal region of H. pylori neutrophil activating protein in the stimulation of neutrophil activation as well as the evidence that the C-terminal region of H. pylori activating protein is indispensable for neutrophil adhesion to endothelial cells, a step necessary to H. pylori inflammation. In addition we show that arabino galactan proteins derived from chios mastic gum, the natural resin of the plant Pistacia lentiscus var. Chia inhibit neutrophil activation in vitro.|Amino Acid Sequence[MESH]|Anti-Bacterial Agents/pharmacology/*therapeutic use[MESH]|Bacterial Proteins/chemistry/genetics/*metabolism[MESH]|Endothelial Cells/cytology/metabolism[MESH]|Helicobacter Infections/*drug therapy[MESH]|Helicobacter pylori/*metabolism[MESH]|Humans[MESH]|Inflammation/*drug therapy/microbiology[MESH]|Mastic Resin[MESH]|Models, Molecular[MESH]|Molecular Sequence Data[MESH]|Neutrophil Activation/drug effects[MESH]|Neutrophils/cytology/drug effects/immunology[MESH]|Pistacia/chemistry[MESH]|Protein Conformation[MESH]|Resins, Plant/chemistry/pharmacology/*therapeutic use[MESH] |