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SRC-3 has a role in cancer other than as a nuclear receptor coactivator Ma G; Ren Y; Wang K; He JInt J Biol Sci 2011[]; 7 (5): 664-72Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is a member of the p160 steroid receptor coactivator family. Since SRC-3 was found to be amplified in breast cancer in 1997, the role of SRC-3 in cancer has been broadly investigated. SRC-3 initially was identified as a transcriptional coactivator for nuclear receptors such as the estrogen receptor (ER), involved in the proliferation of hormone-dependent cancers. However, increasing clinical evidence shows that dysregulation of SRC-3 expression in several human hormone-independent cancers is correlated with pathological factors and clinical prognosis. Recently, both in vivo and in vitro studies demonstrate that SRC-3 may influence a number of cancer cellular processes in several ways independent of nuclear receptor signaling. In addition, an SRC-3 transgenic mice model shows that SRC-3 induces tumors in several mouse tissues. These results indicate that the role of SRC-3 in cancer is not just as a nuclear receptor coactivator. The focus of this review is to examine possible SRC-3 roles in cancer, other than as a nuclear receptor coactivator.|Animals[MESH]|Apoptosis/genetics/physiology[MESH]|Cell Cycle/genetics/physiology[MESH]|Cell Proliferation[MESH]|Humans[MESH]|Mice[MESH]|Neoplasms/genetics/*metabolism[MESH]|Nuclear Receptor Coactivator 3/genetics/*metabolism[MESH]|Nuclear Receptor Coactivators/genetics/*metabolism[MESH] |
