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lüll Intracellular delivery of RNA-based therapeutics using aptamers Thiel KW; Giangrande PHTher Deliv 2010[Dec]; 1 (6): 849-61The clinical potential of siRNAs for silencing genes critical to disease progression is clear, but a fail-proof method for delivering siRNAs to the cytoplasm of diseased tissues or cells has yet to be identified. A variety of delivery approaches have been explored to directly or indirectly couple siRNAs to delivery vehicles. This review explores the use of synthetic single-stranded DNA and RNA aptamers as a means to deliver siRNAs, shRNAs and antisense oligonucleotides for therapeutic intervention. Topics covered include: the advantages and challenges of using aptamers as delivery tools; current aptamer-mediated siRNA delivery platforms for the treatment of cancer and HIV; and emerging methodologies for the identification of aptamers capable of internalizing into target cell types.|Aptamers, Nucleotide/*administration & dosage[MESH]|CD4 Antigens/genetics[MESH]|HIV Envelope Protein gp120/genetics[MESH]|HIV Infections/*drug therapy[MESH]|Humans[MESH]|Neoplasms/*drug therapy[MESH]|RNA, Small Interfering/*administration & dosage[MESH] |