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lüll Adipose tissue remodeling and obesity Sun K; Kusminski CM; Scherer PEJ Clin Invest 2011[Jun]; 121 (6): 2094-101To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that limits healthy expansion. Proper expansion requires a highly coordinated response among many different cell types, including endothelial precursor cells, immune cells, and preadipocytes. There are therefore remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.|Adaptation, Physiological[MESH]|Adipocytes/pathology/physiology[MESH]|Adipose Tissue/blood supply/growth & development/pathology/*physiopathology[MESH]|Animals[MESH]|Cell Division[MESH]|Cell Hypoxia[MESH]|Cell Size[MESH]|Endothelial Cells/physiology[MESH]|Energy Metabolism/*physiology[MESH]|Extracellular Matrix/physiology[MESH]|Fatty Acids/metabolism[MESH]|Humans[MESH]|Inflammation/physiopathology[MESH]|Macrophages/classification/physiology[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Neovascularization, Physiologic[MESH]|Obesity/*physiopathology[MESH]|Weight Loss/physiology[MESH] |