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English Wikipedia
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Immune thrombocytopenia: no longer idiopathic McCrae KCleve Clin J Med 2011[Jun]; 78 (6): 358-73Immune thrombocytopenia (ITP) is a common hematologic disorder. Its pathogenesis involves both accelerated platelet destruction and impaired platelet production. First-line agents are usually effective initially but do not provide long-term responses. Splenectomy remains an effective long-term therapy, as does rituximab (Rituxan) in a subset of patients. Thrombopoietic agents offer a new alternative, although their place in the overall management of ITP remains uncertain.|Adrenal Cortex Hormones/therapeutic use[MESH]|Anti-Inflammatory Agents/therapeutic use[MESH]|Antibodies, Monoclonal, Murine-Derived/therapeutic use[MESH]|Humans[MESH]|Immunologic Factors/therapeutic use[MESH]|Purpura, Thrombocytopenic, Idiopathic/diagnosis/etiology/*therapy[MESH]|Receptors, Thrombopoietin/agonists[MESH]|Rituximab[MESH]|Splenectomy[MESH] |
