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lüll The role of natural killer cells in sepsis Chiche L; Forel JM; Thomas G; Farnarier C; Vely F; Blery M; Papazian L; Vivier EJ Biomed Biotechnol 2011[]; 2011 (ä): 986491Severe sepsis and septic shock are still deadly conditions urging to develop novel therapies. A better understanding of the complex modifications of the immune system of septic patients is needed for the development of innovative immunointerventions. Natural killer (NK) cells are characterized as CD3(-)NKp46(+)CD56(+) cells that can be cytotoxic and/or produce high amounts of cytokines such as IFN-gamma. NK cells are also engaged in crosstalks with other immune cells, such as dendritic cells, macrophages, and neutrophils. During the early stage of septic shock, NK cells may play a key role in the promotion of the systemic inflammation, as suggested in mice models. Alternatively, at a later stage, NK cells-acquired dysfunction could favor nosocomial infections and mortality. Standardized biological tools defining patients' NK cell status during the different stages of sepsis are mandatory to guide potential immuno-interventions. Herein, we review the potential role of NK cells during severe sepsis and septic shock.|*Models, Immunological[MESH]|Animals[MESH]|Humans[MESH]|Killer Cells, Natural/*immunology/*pathology[MESH]|Mice[MESH]|Sepsis/*immunology/*pathology[MESH]|Systemic Inflammatory Response Syndrome/*immunology/*pathology[MESH] |