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  • WT1/EGR1-mediated control of STIM1 expression and function in cancer cells
  • Ritchie MF; Zhou Y; Soboloff J
  • Front Biosci (Landmark Ed) 2011[Jun]; 16 (): 2402-15
  • There have been numerous publications linking Ca(2+) signaling and cancer, however, a clear explanation for this link has remained elusive. We recently identified the oncogenes/tumor suppressors Wilms Tumor Suppressor 1 (WT1) and Early Growth Response 1 (EGR1) as regulators of the expression of STIM1, an essential regulator of Ca(2+) entry in non-excitable cells. The current review focuses on the literature defining both differential Ca(2+) signaling and WT1/EGR1 expression patterns in 6 specific cancer subtypes: Acute Myeloid Leukemia, Wilms Tumor, breast cancer, ovarian cancer, glioblastoma and prostate cancer. For each tumor-type, we have assessed how specific changes in WT1 and EGR1 expression might contribute to aberrant Ca(2+) homeostasis as well as the therapeutic potential of these observations.
  • |Brain Neoplasms/genetics/metabolism[MESH]
  • |Breast Neoplasms/genetics/metabolism[MESH]
  • |Calcium Signaling[MESH]
  • |Early Growth Response Protein 1/genetics/*metabolism[MESH]
  • |Female[MESH]
  • |Gene Expression Regulation, Neoplastic[MESH]
  • |Genes, Tumor Suppressor[MESH]
  • |Genes, Wilms Tumor[MESH]
  • |Glioblastoma/genetics/metabolism[MESH]
  • |Humans[MESH]
  • |Leukemia, Myeloid, Acute/genetics/metabolism[MESH]
  • |Male[MESH]
  • |Membrane Proteins/genetics/*metabolism[MESH]
  • |Models, Biological[MESH]
  • |Neoplasm Proteins/genetics/*metabolism[MESH]
  • |Neoplasms/genetics/*metabolism[MESH]
  • |Oncogenes[MESH]
  • |Ovarian Neoplasms/genetics/metabolism[MESH]
  • |Prostatic Neoplasms/genetics/metabolism[MESH]
  • |Proto-Oncogene Proteins c-bcl-2/metabolism[MESH]
  • |Stromal Interaction Molecule 1[MESH]
  • |Transient Receptor Potential Channels/metabolism[MESH]
  • |WT1 Proteins/*metabolism[MESH]
  • |Wilms Tumor/genetics/metabolism[MESH]

  • *{{pmid21622185}}
    *<b>[ WT1/EGR1-mediated control of STIM1 expression and function in cancer cells ]</b> Front Biosci (Landmark Ed) 2011; 16() ; 2402-15 Ritchie MF; Zhou Y; Soboloff J


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    Front Biosci (Landmark Ed)

    2402 .16 2011