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lüll Can molecular cell biology explain chromosome motions?Shain DH; Gagliardi LJTheor Biol Med Model 2011[May]; 8 (ä): 15BACKGROUND: Mitotic chromosome motions have recently been correlated with electrostatic forces, but a lingering "molecular cell biology" paradigm persists, proposing binding and release proteins or molecular geometries for force generation. RESULTS: Pole-facing kinetochore plates manifest positive charges and interact with negatively charged microtubule ends providing the motive force for poleward chromosome motions by classical electrostatics. This conceptual scheme explains dynamic tracking/coupling of kinetochores to microtubules and the simultaneous depolymerization of kinetochore microtubules as poleward force is generated. CONCLUSION: We question here why cells would prefer complex molecular mechanisms to move chromosomes when direct electrostatic interactions between known bound charge distributions can accomplish the same task much more simply.|*Cell Biology[MESH]|*Molecular Biology[MESH]|*Motion[MESH]|Biomechanical Phenomena/physiology[MESH]|Chromosomes/*physiology[MESH]|Kinetochores/physiology[MESH]|Nanostructures[MESH]|Static Electricity[MESH] |