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Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions Rogosnitzky M; Danks RPharmacol Rep 2011[]; 63 (2): 337-47Cepharanthine (CEP) is a naturally occurring alkaloid extracted from the plant Stephania cepharantha Hayata. It has been widely used in Japan for more than 40 years to treat a wide variety of acute and chronic diseases. CEP inhibits tumor necrosis factor (TNF)-alpha-mediated NFkappaB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppresses cytokine production. It has also been shown to scavenge free radicals and to have a protective effect against some of the responses mediated by pro-inflammatory cytokines such as TNF-alpha, interleukin (IL)-1beta and IL6. CEP has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported.|Animals[MESH]|Anti-Inflammatory Agents, Non-Steroidal/adverse effects/isolation & purification/pharmacology[MESH]|Antineoplastic Agents, Phytogenic/adverse effects/isolation & purification/pharmacology[MESH]|Benzylisoquinolines/adverse effects/isolation & purification/*pharmacology[MESH]|Humans[MESH]|Japan[MESH]|Medicine, East Asian Traditional[MESH]|Stephania/*chemistry[MESH] |
