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Perils and pitfalls regarding differential diagnosis and treatment of primary cutaneous anaplastic large-cell lymphoma Diamantidis MD; Myrou ADScientificWorldJournal 2011[May]; 11 (ä): 1048-55Primary cutaneous anaplastic large-cell lymphoma (PC-ALCL), belonging to the CD30+ T-cell lymphoproliferative disorders (PCLPDs), is a rare T-cell lymphoma, presenting on the skin and characterized by very good prognosis and response to treatment in the majority of cases. Nevertheless, PC-ALCL must be distinguished from secondary skin lesions in systemic ALCL, which confer a poor prognosis, and other CD30+ PCLPDs, reactive conditions, or borderline cases. Given their rarity and heterogeneity, these entities represent diagnostic and therapeutic challenges, thus requiring a multidisciplinary approach and expertise to ensure appropriate diagnosis and management. There are several perils and pitfalls that exist regarding the differential diagnosis, the possible progression, and the treatment of PC-ALCL. Careful staging, correlation of clinical findings with histopathology and immunopathology, and thorough follow-up are essential in order to achieve a correct diagnosis and proper treatment of the disease.|Anaplastic Lymphoma Kinase[MESH]|Diagnosis, Differential[MESH]|Humans[MESH]|Ki-1 Antigen/metabolism[MESH]|Lymphoma, Primary Cutaneous Anaplastic Large Cell/*diagnosis/*therapy[MESH]|Lymphomatoid Papulosis/diagnosis/therapy[MESH]|Prognosis[MESH]|Rare Diseases/diagnosis/therapy[MESH]|Receptor Protein-Tyrosine Kinases/analysis[MESH]|Skin Neoplasms/*diagnosis/*therapy[MESH] |
