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Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target Wang H; Lafdil F; Kong X; Gao BInt J Biol Sci 2011[Apr]; 7 (5): 536-50Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is activated by many cytokines and growth factors and plays a key role in cell survival, proliferation, and differentiation. STAT3 activation is detected virtually in all rodent models of liver injury and in human liver diseases. In this review, we highlight recent advances of STAT3 signaling in liver injury, steatosis, inflammation, regeneration, fibrosis, and hepatocarcinogenesis. The cytokines and small molecules that activate STAT3 in hepatocytes may have therapeutic benefits to treat acute liver injury, fatty liver disease, and alcoholic hepatitis, while blockage of STAT3 may have a therapeutic potential to prevent and treat liver cancer.|*Liver Regeneration[MESH]|Animals[MESH]|Fatty Liver/metabolism[MESH]|Glucose/metabolism[MESH]|Hepatocytes/metabolism[MESH]|Humans[MESH]|Liver Diseases/*metabolism[MESH]|Molecular Targeted Therapy[MESH]|STAT3 Transcription Factor/*metabolism[MESH]|Signal Transduction[MESH] |
