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lüll Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targets Schmitt C; Sako N; Bagot M; Huang Y; Gaulard P; Bensussan AJ Biomed Biotechnol 2011[]; 2011 (ä): 790871Extranodal natural killer (NK)/T-cell lymphoma of nasal type (NKTCL) is a malignant disorder of cytotoxic lymphocytes of NK or more rarely T cells associated with clonal Epstein-Barr virus infection. Extranodal NKTCL is rare in Western countries, but in Asia and Central and South America it can account for up to 10% of non-Hodgkin's lymphomas. It is an aggressive neoplasm with very poor prognosis. Although the pathogenesis of extranodal NKTCL remains poorly understood, some insights have been gained in the recent years, especially from genome-wide studies. Based on our own experience and knowledge of the literature, we here review some of the genomic and functional pathway alterations observed in NKTCL that could provide a rationale for the development of innovative therapeutic strategies.|Cytotoxicity, Immunologic[MESH]|Epstein-Barr Virus Infections/complications[MESH]|Humans[MESH]|Lymphoma, Extranodal NK-T-Cell/complications/*genetics/immunology/virology[MESH]|Natural Killer T-Cells/immunology/pathology[MESH]|Signal Transduction/immunology[MESH]|Viral Proteins/metabolism[MESH] |