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English Wikipedia
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Tumour suppressor function of protein tyrosine phosphatase receptor-T Scott A; Wang ZBiosci Rep 2011[Oct]; 31 (5): 303-7It has long been thought that PTPs (protein tyrosine phosphatases) normally function as tumour suppressors. Recent high-throughput mutational analysis identified loss-of-function mutations in six PTPs in human colon cancers, providing critical cancer genetics evidence that PTPs can act as tumour suppressor genes. PTPRT (protein tyrosine phosphatase receptor-T), a member of the family of type IIB receptor-like PTPs, is the most frequently mutated PTP among them. Consistent with the notion that PTPRT is a tumour suppressor, PTPRT knockout mice are hypersensitive to AOM (azoxymethane)-induced colon cancer. The present review focuses on the physiological and pathological functions of PTPRT as well as the cellular pathways regulated by this phosphatase.|Animals[MESH]|Cell Transformation, Neoplastic/chemistry/*genetics[MESH]|Genetic Predisposition to Disease/genetics[MESH]|Humans[MESH]|Receptor-Like Protein Tyrosine Phosphatases, Class 2/chemistry/*physiology[MESH]|Tumor Suppressor Proteins/chemistry/*physiology[MESH] |
