Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Buffering and the evolution of chromosome-wide gene regulation Stenberg P; Larsson JChromosoma 2011[Jun]; 120 (3): 213-25Copy number variation (CNV) in terms of aneuploidies of both entire chromosomes and chromosomal segments is an important evolutionary driving force, but it is inevitably accompanied by potentially problematic variations in gene doses and genomic instability. Thus, a delicate balance must be maintained between mechanisms that compensate for variations in gene doses (and thus allow such genomic variability) and selection against destabilizing CNVs. In Drosophila, three known compensatory mechanisms have evolved: a general segmental aneuploidy-buffering system and two chromosome-specific systems. The two chromosome-specific systems are the male-specific lethal complex, which is important for dosage compensation of the male X chromosome, and Painting of fourth, which stimulates expression of the fourth chromosome. In this review, we discuss the origin and function of buffering and compensation using Drosophila as a model.|*DNA Copy Number Variations[MESH]|*Evolution, Molecular[MESH]|*Gene Expression Regulation[MESH]|Aneuploidy[MESH]|Animals[MESH]|Chromosomes/*genetics[MESH]|Dosage Compensation, Genetic[MESH]|Drosophila/genetics[MESH]|Female[MESH]|Gene Dosage[MESH]|Genes, Lethal/genetics[MESH]|Genomic Instability[MESH]|Humans[MESH]|Male[MESH]|Phylogeny[MESH]|Selection, Genetic[MESH]|Transcription, Genetic[MESH] |
