Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Anaplastic lymphoma kinase in human cancer Barreca A; Lasorsa E; Riera L; Machiorlatti R; Piva R; Ponzoni M; Kwee I; Bertoni F; Piccaluga PP; Pileri SA; Inghirami GJ Mol Endocrinol 2011[Aug]; 47 (1): R11-23The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)-ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK-RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.|Anaplastic Lymphoma Kinase[MESH]|Antineoplastic Agents/pharmacology[MESH]|CSK Tyrosine-Protein Kinase[MESH]|Crizotinib[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins/metabolism[MESH]|Lymphoma/genetics/*metabolism[MESH]|Mutation[MESH]|Neoplasms/genetics/metabolism[MESH]|Phosphatidylinositol 3-Kinases/metabolism[MESH]|Phospholipase C gamma/metabolism[MESH]|Piperidines/pharmacology[MESH]|Protein-Tyrosine Kinases/metabolism[MESH]|Proto-Oncogene Proteins p21(ras)/metabolism[MESH]|Proto-Oncogene Proteins/metabolism[MESH]|Pyrazoles[MESH]|Pyridines/pharmacology[MESH]|Receptor Protein-Tyrosine Kinases/antagonists & inhibitors/genetics/*metabolism[MESH]|Signal Transduction[MESH]|Transcriptional Activation[MESH]|Translocation, Genetic[MESH]|Up-Regulation/genetics[MESH]|src-Family Kinases[MESH] |
