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Metastatic balloon cell malignant melanoma: a case report and literature review Lee L; Zhou F; Simms A; Wieczorek R; Fang Y; Subietas-Mayol A; Wang B; Heller P; Huang H; Pei Z; Osman I; Meehan S; Lee PInt J Clin Exp Pathol 2011[Mar]; 4 (3): 315-21A case of metastatic balloon cell malignant melanoma (BCMM) is presented. The balloon melanoma cells (BMC) were absent in the shave biopsy of the primary lesion and present as a minor component in the wide and deep excision. A subsequent right neck lymph node metastasis showed complete replacement of the lymph node by large, foamy cells. Though the tumor was amelanocytic and Fontana-Masson stain failed to reveal melanin, it stained positively for S-100, HMB-45, and Melan-A. Ultrastructurally, the foamy cells were characterized by cytoplasmic vacuolization and a lack of melanosomes. The differential diagnosis of metastatic balloon cell malignant melanoma is broad, and clinicopathologic correlation may play a critical role in achieving the correct diagnosis.|Aged[MESH]|Humans[MESH]|Lymphatic Metastasis[MESH]|Male[MESH]|Melanoma/diagnostic imaging/*secondary[MESH]|Radiography[MESH]|Silver Staining[MESH]|Skin Neoplasms/diagnostic imaging/*pathology[MESH] |
