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lüll Caveolin-1 in sarcomas: friend or foe?Sainz-Jaspeado M; Martin-Liberal J; Lagares-Tena L; Mateo-Lozano S; Garcia del Muro X; Tirado OMOncotarget 2011[Apr]; 2 (4): 305-12Sarcomas represent a heterogeneous group of tumors with a complex and difficult reproducible classification. Their pathogenesis is poorly understood and there are few effective treatment options for advanced disease. Caveolin-1 is a multifunctional scaffolding protein with multiple binding partners that regulates multiple cancer-associated processes including cellular transformation, tumor growth, cell death and survival, multidrug resistance, angiogenesis, cell migration and metastasis. However, ambiguous roles have been ascribed to caveolin-1 in signal transduction and cancer, including sarcomas. In particular, evidence indicating that caveolin-1 function is cell context dependent has been repeatedly reported. Caveolin-1 appears to act as a tumor suppressor protein at early stages of cancer progression. In contrast, a growing body of evidence indicates that caveolin-1 is up-regulated in several multidrug-resistant and metastatic cancer cell lines and human tumor specimens. This review is focused on the role of caveolin-1 in several soft tissue and bone sarcomas and discusses the use of this protein as a potential diagnostic and prognostic marker and as a therapeutic target.|Animals[MESH]|Biomarkers, Tumor/genetics/metabolism/physiology[MESH]|Bone Neoplasms/diagnosis/etiology/genetics/pathology[MESH]|Caveolin 1/genetics/metabolism/*physiology[MESH]|Disease Progression[MESH]|Humans[MESH]|Models, Biological[MESH]|Molecular Targeted Therapy[MESH]|Neoplasm Metastasis[MESH]|Sarcoma/*diagnosis/*etiology/genetics/pathology[MESH]|Soft Tissue Neoplasms/diagnosis/etiology/genetics/pathology[MESH] |