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lüll Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Balasubramanian S; Hurley LH; Neidle SNat Rev Drug Discov 2011[Apr]; 10 (4): 261-75G-quadruplexes are four-stranded DNA structures that are over-represented in gene promoter regions and are viewed as emerging therapeutic targets in oncology, as transcriptional repression of oncogenes through stabilization of these structures could be a novel anticancer strategy. Many gene promoter G-quadruplexes have physicochemical properties and structural characteristics that might make them druggable, and their structural diversity suggests that a high degree of selectivity might be possible. Here, we describe the evidence for G-quadruplexes in gene promoters and discuss their potential as therapeutic targets, as well as progress in the development of strategies to harness this potential through intervention with small-molecule ligands.|*Drug Delivery Systems[MESH]|*G-Quadruplexes/drug effects[MESH]|Animals[MESH]|Antineoplastic Agents/pharmacology[MESH]|Drug Design[MESH]|Humans[MESH]|Neoplasms/*drug therapy/pathology[MESH]|Promoter Regions, Genetic[MESH] |