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lüll Intermittent preventive therapy for malaria: arguments in favour of artesunate and sulphamethoxypyrazine - pyrimethamine combination Jansen FHMalar J 2011[Mar]; 10 (ä): 70Recent publications put a serious warning regarding the inefficacy of sulphadoxine-pyrimethamine (SP) for the intermittent preventive treatment of malaria in young children (IPTi). Recommendations for other therapies are being made. By using a different and better sulphonamide (sulphamethoxypyrazine), it is possible to manufacture fixed dose combination pills with artesunate and pyrimethamine. This combination permits a full therapy over 24 hours (dosing interval being 12 hours). It is recommended that this combination should be tested in future field studies of IPTi.|Antimalarials/*administration & dosage/therapeutic use[MESH]|Artemisinins/*administration & dosage/therapeutic use[MESH]|Artesunate[MESH]|Child[MESH]|Drug Combinations[MESH]|Drug Resistance, Multiple[MESH]|Female[MESH]|Humans[MESH]|Infant[MESH]|Malaria/*drug therapy/*prevention & control[MESH]|Plasmodium/drug effects[MESH]|Pyrimethamine/*administration & dosage/therapeutic use[MESH]|Sulfalene/*administration & dosage/therapeutic use[MESH] |