Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?Seely KA; Prather PL; James LP; Moran JHMol Interv 2011[Feb]; 11 (1): 36-51The principal psychoactive component of marijuana, Delta(9)-tetrahydrocannabinol (THC), activates CB1 cannabinoid receptors (CB1Rs). Unfortunately, pharmacological research into the design of effective THC analogs has been hampered by psychiatric side effects. THC-based drug design of a less academic nature, however, has led to the marketing of "synthetic marijuana," labeled as K2 or "Spice," among other terms, which elicits psychotropic actions via CB1R activation. Because of structural dissimilarity to THC, the active ingredients of K2/Spice preparations are widely unregulated. The K2/Spice "phenomenon" provides a context for considering whether marijuana-based drugs will truly provide innovative therapeutics or merely perpetuate drug abuse.|Animals[MESH]|Cannabinoids/*adverse effects/chemistry/pharmacology/*therapeutic use[MESH]|Cannabis/*adverse effects/*chemistry[MESH]|Clinical Trials as Topic[MESH]|Designer Drugs/adverse effects/chemistry/pharmacology/*therapeutic use[MESH]|Humans[MESH]|Illicit Drugs/adverse effects/chemistry/*pharmacology[MESH]|Models, Biological[MESH] |