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lüll Myositis-related interstitial lung disease and antisynthetase syndrome Solomon J; Swigris JJ; Brown KKJ Bras Pneumol 2011[Jan]; 37 (1): 100-9In patients with myositis, the lung is commonly involved, and the presence of anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies marks the presence or predicts the development of interstitial lung disease (ILD). A distinct clinical entity-antisynthetase syndrome-is characterized by the presence of anti-ARS antibodies, myositis, ILD, fever, arthritis, Raynaud's phenomenon, and mechanic's hands. The most common anti-ARS antibody is anti-Jo-1. More recently described anti-ARS antibodies might confer a phenotype that is distinct from that of anti-Jo-1-positive patients and is characterized by a lower incidence of myositis and a higher incidence of ILD. Among patients with antisynthetase syndrome-related ILD, the response to immunosuppressive medications is generally, but not universally, favorable.|Amino Acyl-tRNA Synthetases/*blood[MESH]|Antibodies, Antinuclear/blood[MESH]|Antigens, Human Platelet/blood[MESH]|Autoantibodies/*blood[MESH]|Humans[MESH]|Lung Diseases, Interstitial/diagnosis/*immunology/therapy[MESH]|Myositis/diagnosis/*immunology/therapy[MESH] |