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lüll Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic Koehler-Santos P; Izetti P; Abud J; Pitroski CE; Cossio SL; Camey SA; Tarta C; Damin DC; Contu PC; Rosito MA; Ashton-Prolla P; Prolla JCWorld J Gastroenterol 2011[Feb]; 17 (6): 766-73AIM: To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern Brazil. METHODS: A consecutive sample of patients with CRC were interviewed regarding personal and family histories of cancer. Clinical data and pathology features of the tumor were obtained from chart review. RESULTS: Of the 212 CRC patients recruited, 61 (29%) reported a family history of CRC, 45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary CRC. Family histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients, respectively. Twenty percent of the colorectal tumors had features of the high microsatellite instability phenotype, which was associated with younger age at CRC diagnosis and with Bethesda criteria (P < 0.001). Only 5.3% of the patients above age 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk assessment. CONCLUSION: A significant proportion of patients with CRC were at high risk for LS. Education and training of health care professionals are essential to ensure proper management.|*Genetic Predisposition to Disease[MESH]|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Brazil[MESH]|Colorectal Neoplasms, Hereditary Nonpolyposis/*genetics/physiopathology[MESH]|Colorectal Neoplasms/*genetics/pathology/*surgery[MESH]|Colorectal Surgery[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Microsatellite Instability[MESH]|Middle Aged[MESH]|Risk Factors[MESH]|Young Adult[MESH] |