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lüll High-dose vitamin D: helpful or harmful?Hansen KECurr Rheumatol Rep 2011[Jun]; 13 (3): 257-64If the optimal serum 25(OH)D level for skeletal health is 30 ng/mL or greater, then vitamin D insufficiency is widespread, affecting about 75% of adults based on a recent survey of more than 20,000 Americans. However, after a comprehensive analysis of existing research studies, the Institute of Medicine recently concluded that nearly all individuals are vitamin D replete when their 25(OH)D levels are 20 ng/mL or greater. Furthermore, two recent publications challenge the belief that 25(OH)D levels greater than 30 ng/mL are optimal for bone health. In a randomized, placebo-controlled trial, high-dose, once-yearly vitamin D therapy increased the incidence of fractures and falls. The second study reported that high-dose vitamin D did not reduce levels of parathyroid hormone or bone resorption among adults with 25(OH)D levels less than 32 ng/mL at baseline. It is time to question whether serum 25(OH)D levels of 30 ng/mL or greater are necessary for all individuals.|Bone Density/drug effects[MESH]|Bone Resorption/drug therapy[MESH]|Calcium/administration & dosage[MESH]|Dose-Response Relationship, Drug[MESH]|Drug Therapy, Combination[MESH]|Female[MESH]|Fractures, Bone/prevention & control[MESH]|Humans[MESH]|Male[MESH]|Meta-Analysis as Topic[MESH]|Nutrition Policy[MESH]|Randomized Controlled Trials as Topic[MESH]|Vitamin D/*adverse effects/*therapeutic use[MESH] |