Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Juvenile neuronal ceroid-lipofuscinosis: clinical and molecular investigation in a large family in Brazil Valadares ER; Pizarro MX; Oliveira LR; Amorim RH; Pinheiro TM; Grieben U; Santos HH; Queiroz RR; Lopes Gde C; Godard ALArq Neuropsiquiatr 2011[Feb]; 69 (1): 13-8OBJECTIVE: Juvenile Neuronal Ceroid-Lipofuscinosis (JNCL, CLN 3, Batten Disease) (OMIM #204200) belongs to the most common group of neurodegenerative disorders of childhood. We report the clinical data and molecular analysis of a large Brazilian family. METHOD: Family composed of two consanguineous couples and thirty-two children. Clinical data of ten JNCL patients and molecular analyses on 13 participants were obtained. RESULTS: The large 1.02 kb deletion was detected. The most severe phenotype, with autistic behavior, tics and parkinsonism was seen in a 12-year-old female and a milder phenotype in a 14-year-old male. Nyctalopia was the first symptom in one deceased child. The visual loss of six patients has been first observed in the school and not at home. CONCLUSION: The report highlights the phenotypical intrafamily variation in 10 affected children of this family. The molecular investigation of this large family in our metabolic center turned possible the diagnosis, right approach and genetic counseling.|*Consanguinity[MESH]|*Gene Deletion[MESH]|Adolescent[MESH]|Brazil[MESH]|Cause of Death[MESH]|Child[MESH]|Electrophoresis, Agar Gel[MESH]|Exons/genetics[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Neuronal Ceroid-Lipofuscinoses/*genetics[MESH]|Night Blindness/genetics[MESH]|Pedigree[MESH]|Phenotype[MESH]|Vision Disorders/genetics[MESH] |