Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Role of the endothelium in inflammatory bowel diseases Cromer WE; Mathis JM; Granger DN; Chaitanya GV; Alexander JSWorld J Gastroenterol 2011[Feb]; 17 (5): 578-93Inflammatory bowel diseases (IBD) are a complex group of diseases involving alterations in mucosal immunity and gastrointestinal physiology during both initiation and progressive phases of the disease. At the core of these alterations are endothelial cells, whose continual adjustments in structure and function coordinate vascular supply, immune cell emigration, and regulation of the tissue environment. Expansion of the endothelium in IBD (angiogenesis), mediated by inflammatory growth factors, cytokines and chemokines, is a hallmark of active gut disease and is closely related to disease severity. The endothelium in newly formed or inflamed vessels differs from that in normal vessels in the production of and response to inflammatory cytokines, growth factors, and adhesion molecules, altering coagulant capacity, barrier function and blood cell recruitment in injury. This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelium contributing to these conditions.|Animals[MESH]|Blood Coagulation/immunology[MESH]|Blood Platelets/immunology[MESH]|Cell Adhesion Molecules/metabolism[MESH]|Chemokines/immunology[MESH]|Colorectal Neoplasms/etiology/pathology[MESH]|Cytokines/immunology[MESH]|Endothelial Cells/cytology/immunology[MESH]|Endothelium, Vascular/*physiology/*physiopathology[MESH]|Humans[MESH]|Inflammatory Bowel Diseases/pathology/*physiopathology/therapy[MESH]|Intercellular Signaling Peptides and Proteins/metabolism[MESH]|Intestines/*blood supply/immunology/pathology[MESH]|Neovascularization, Pathologic/complications[MESH]|Nitric Oxide Synthase Type III/metabolism[MESH]|Nitric Oxide/metabolism[MESH]|Stem Cells/physiology[MESH]|Toll-Like Receptors/immunology[MESH] |
