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lüll The pursuit of oncotargets through understanding defective cell regulation Qiao M; Shi Q; Pardee ABOncotarget 2010[Nov]; 1 (7): 544-51More effective anticancer agents are essential, as has too often been demonstrated by the paucity of therapeutics which preserve life. Their discovery is very difficult. Many approaches are being applied, from testing folk medicines to automated high throughput screening of large chemical libraries. Mutations in cancer cells create dysfunctional regulatory systems. This Perspective summarizes an approach to applying defective molecular control mechanisms as oncotargets on which drug discoveries against cancer can be based.|Animals[MESH]|Antineoplastic Agents/*therapeutic use[MESH]|Cell Cycle Proteins/genetics/isolation & purification/*physiology[MESH]|Cell Growth Processes/genetics[MESH]|Cell Survival/genetics/physiology[MESH]|Comprehension[MESH]|Drug Discovery/methods/*trends[MESH]|Humans[MESH]|Molecular Targeted Therapy/*methods/trends[MESH]|Neoplasms/*drug therapy/genetics/pathology[MESH] |