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lüll On the function of the mammalian renal papilla and the peristalsis of the surrounding pelvis Schmidt-Nielsen B; Schmidt-Nielsen BActa Physiol (Oxf) 2011[Jul]; 202 (3): 379-85This is an informal personal review of the development over time of my ideas about the concentrating mechanism of the mammalian renal papilla. It had been observed that animals with a need to produce a concentrated urine have a long renal papilla. I saw the function of the long papilla in desert rodents as an elongation of the counter-current concentrating mechanism of the inner medulla. This model led me to overlook contrary evidence. For example, in many experiments, the final urine has a higher osmolality than that of the tissue at the tip of the papilla. In addition, we had observations of the peristalsis of the renal pelvis surrounding the papilla. The urine concentration falls if the peristalsis is stopped. I was wrong; together, these lines of evidence show that the renal papilla is not just an elongation of the inner medulla. We are left without a full explanation of the concentrating mechanism of the mammalian renal papilla. It is hoped that other researchers will tackle this interesting problem.|Animals[MESH]|Kidney Concentrating Ability/*physiology[MESH]|Kidney Medulla/anatomy & histology/*physiology[MESH]|Kidney Pelvis/*anatomy & histology/*physiology[MESH]|Osmolar Concentration[MESH]|Peristalsis/*physiology[MESH]|Urea/metabolism[MESH]|Urine/chemistry[MESH] |