Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability Aly A; Ganesan SJ Mol Cell Biol 2011[Feb]; 3 (1): 66-74BRCA1 plays a critical role in the regulation of homologous recombination (HR)-mediated DNA double-strand break repair. BRCA1-deficient cancers have evolved to tolerate loss of BRCA1 function. This renders them vulnerable to agents, such as PARP inhibitors, that are conditionally 'synthetic lethal' with their underlying repair defect. Recent studies demonstrate that BRCA1-deficient cells may acquire resistance to these agents by partially correcting their defect in HR-mediated repair, either through reversion mutations in BRCA1 or through 'synthetic viable' loss of 53BP1. These findings and their clinical implications will be reviewed in this article.|Animals[MESH]|BRCA1 Protein/*genetics[MESH]|DNA Breaks, Double-Stranded[MESH]|DNA Repair[MESH]|Drug Resistance, Neoplasm[MESH]|Genes, Lethal/*genetics[MESH]|Humans[MESH]|Intracellular Signaling Peptides and Proteins/*genetics[MESH]|Neoplasms/genetics[MESH]|Poly(ADP-ribose) Polymerases/*genetics/metabolism[MESH]|Recombination, Genetic[MESH]|Tumor Suppressor p53-Binding Protein 1[MESH] |