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lüll Genomic instability and cancer: an introduction Shen ZJ Mol Cell Biol 2011[Feb]; 3 (1): 1-3Genomic instability refers to an increased tendency of alterations in the genome during the life cycle of cells. It is a major driving force for tumorigenesis. During a cell division, genomic instability is minimized by four major mechanisms: high-fidelity DNA replication in S-phase, precise chromosome segregation in mitosis, error free repair of sporadic DNA damage, and a coordinated cell cycle progression. This introduction summarizes the major molecular processes that contribute to these mechanisms in the context of prevention of genomic instability and tumorigenesis.|Animals[MESH]|Cell Division[MESH]|Chromosome Segregation[MESH]|DNA Replication[MESH]|Genomic Instability/*genetics[MESH]|Humans[MESH]|Mitosis/genetics[MESH]|Neoplasms/*genetics[MESH]|S Phase/genetics[MESH] |