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The role of RhoA/Rho kinase pathway in endothelial dysfunction Yao L; Romero MJ; Toque HA; Yang G; Caldwell RB; Caldwell RWJ Cardiovasc Dis Res 2010[Oct]; 1 (4): 165-70Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.ä |
