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lüll Occupational reproductive function abnormalities and bladder cancer in Korea Park J; Shin KS; Kim YJ Korean Med Sci 2010[Dec]; 25 (Suppl): S41-5The purpose of this study was to review occupational reproductive abnormalities and occupational bladder cancer in Korea and to discuss their toxicological implications. Reproductive dysfunction as a result of 2-bromopropane poisoning was first reported in Korean workers. In 1995, 23 of the 33 workers (25 female and 8 male workers) who were exposed to 2-bromopropane during the assembly of tactile switch parts developed reproductive and/or hematopoietic disorders. A total of 17 (68%) workers were diagnosed with ovarian failure. Two of the eight male workers experienced azoospermia and four workers experienced some degree of oligospermia or reduced sperm motility. In summary, 2-bromopropane poisoning caused severe reproductive effects in Korean workers. The prognosis was poor for reproductive dysfunction. A few cases of occupational bladder cancer have been reported in Korea, whereas other cancers of the urinary tract have not been reported after occupational exposure. A few cases of benzidine-induced cancer have been reported in Korea and 592 workers in Japan have received compensation for benzidine and beta-naphthylamine-induced cancer. In conclusion, a few cases of benzidine-induced occupational bladder cancer have been reported in Korea. However, benzidine-induced bladder cancer will likely be an important occupational health issue in Korea in the coming years.|2-Naphthylamine/toxicity[MESH]|Azoospermia/chemically induced/epidemiology[MESH]|Benzidines/toxicity[MESH]|Female[MESH]|Humans[MESH]|Hydrocarbons, Brominated/toxicity[MESH]|Infertility/*chemically induced/*epidemiology[MESH]|Male[MESH]|Occupational Diseases/*chemically induced/*epidemiology[MESH]|Occupational Exposure/adverse effects[MESH]|Oligospermia/chemically induced/epidemiology[MESH]|Primary Ovarian Insufficiency/chemically induced/epidemiology[MESH]|Republic of Korea[MESH]|Sperm Motility/drug effects[MESH]|Urinary Bladder Neoplasms/*chemically induced/*epidemiology[MESH] |