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lüll Systematic review on the surgical treatment for T1 gallbladder cancer Lee SE; Jang JY; Lim CS; Kang MJ; Kim SWWorld J Gastroenterol 2011[Jan]; 17 (2): 174-80AIM: To evaluate the efficacy of simple and extended cholecystectomy for mucosa (T1a) or muscularis (T1b) gallbladder (GB) cancer. METHODS: Original studies on simple and extended cholecystectomy for T1a or T1b GB cancer were searched from MEDLINE (PubMed), Cochrane Library, EMBase, and CancerLit using the search terms of GB, cancer/carcinoma/tumor/neoplasm. RESULTS: Twenty-nine out of the 2312 potentially relevant publications met the eligibility criteria. Of the 1266 patients with GB cancer included in the publications, 706 (55.8%) and 560 (44.2%) had T1a and T1b GB cancer, respectively. Simple cholecystectomy for T1a and T1b GB cancer was performed in 590 (83.6%) and 375 (67.0%) patients, respectively (P < 0.01). In most series, the treatment of choice was simple cholecystectomy for T1a GB cancer patients with a 5-year survival rate of 100%. Lymph node metastasis was detected in 10.9% of the T1b GB cancer patients and in 1.8% of the T1a GB cancer patients, respectively (P < 0.01). Eight patients (1.1%) with T1a GB cancer and 52 patients (9.3%) with T1b GB cancer died of recurrent GB cancer (P < 0.01). CONCLUSION: Simple cholecystectomy represents the adequate treatment of T1a GB cancer. There is no definite evidence that extended cholecystectomy is advantageous over simple cholecystectomy for T1b GB cancer.|*Surgical Procedures, Operative[MESH]|Cholecystectomy, Laparoscopic/*methods[MESH]|Cholecystectomy/methods[MESH]|Gallbladder Neoplasms/*surgery[MESH]|Gastric Mucosa/surgery[MESH]|Humans[MESH]|Laparoscopy/methods[MESH]|Lymphatic Metastasis[MESH]|Randomized Controlled Trials as Topic[MESH]|Recurrence[MESH]|Treatment Outcome[MESH] |