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lüll The genomic landscapes of inflammation Natoli G; Ghisletti S; Barozzi IGenes Dev 2011[Jan]; 25 (2): 101-6Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses.|*Gene Expression Regulation[MESH]|*Genome[MESH]|Animals[MESH]|Humans[MESH]|Inflammation/*genetics[MESH]|Macrophages/metabolism[MESH]|Transcription Factors/*metabolism[MESH] |