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lüll Intratumoral expression of IL-17 and its prognostic role in gastric adenocarcinoma patients Chen JG; Xia JC; Liang XT; Pan K; Wang W; Lv L; Zhao JJ; Wang QJ; Li YQ; Chen SP; He J; Huang LX; Ke ML; Chen YB; Ma HQ; Zeng ZW; Zhou ZW; Chang AE; Li QInt J Biol Sci 2011[Jan]; 7 (1): 53-60In this study, we characterized the intratumoral expression of IL-17 and CD8(+) TILs in gastric adenocarcinoma patients after resection and determined the correlation between the survival probability of gastric adenocarcinoma patients and the expression of IL-17 in tumor. Expression of IL-17 and CD8 was assessed by immunohistochemistry, and the prognostic effects of intratumoral IL-17 expression and CD8(+) TILs were evaluated by Cox regression and Kaplan-Meier analysis. Immunohistochemical detection revealed the presence of IL-17 and CD8(+) cells in gastric adenocarcinoma tissue samples (90.6%, 174 out of 192 patients and 96.9%, 186 out of 192 patients, respectively). We have also found that intratumoral IL-17 expression was significantly correlated with age (p=0.004) and that the number of CD8(+)TILs was significantly correlated with UICC staging (p=0.012) and the depth of tumor invasion (p=0.022). The five-year overall survival probability among patients intratumorally expressing higher levels of IL-17 was significantly better than those expressing lower levels of IL-17 (p=0.036). Multivariate Cox proportional hazard analyses revealed that intratumoral IL-17 expression (HR: 0.521; 95% CI: 0.329-0.823; p=0.005) was an independent factor affecting the five-year overall survival probability. We conclude that low levels of intratumoral IL-17 expression may indicate poor prognosis in gastric adenocarcinoma patients.|Adenocarcinoma/*diagnosis/metabolism/mortality[MESH]|Adolescent[MESH]|Adult[MESH]|Age Factors[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|CD8 Antigens/metabolism[MESH]|Female[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Interleukin-17/*metabolism[MESH]|Kaplan-Meier Estimate[MESH]|Male[MESH]|Middle Aged[MESH]|Predictive Value of Tests[MESH]|Prognosis[MESH]|Stomach Neoplasms/*diagnosis/metabolism/mortality[MESH] |