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lüll The neuroendocrine basis of anorexia nervosa and its impact on bone metabolism Misra M; Klibanski ANeuroendocrinology 2011[]; 93 (2): 65-73Anorexia nervosa (AN) is a condition of profound undernutrition associated with alterations in various neuroendocrine axes, many of which contribute to a marked impairment in bone accrual and low bone mineral density. This review focuses on changes in the hypothalamo-pituitary-gonadal axis, the growth hormone insulin-like growth factor-1 axis, and the hypothalamo-pituitary-adrenal axis in AN, as well as alterations in various appetite-regulating hormones. In addition, the review discusses low bone mineral density and altered bone microarchitecture in AN, the pathophysiology underlying impaired bone metabolism, and possible therapeutic strategies to optimize bone health.|Anorexia Nervosa/drug therapy/*metabolism/*physiopathology[MESH]|Bone Density Conservation Agents/therapeutic use[MESH]|Bone Density/drug effects/physiology[MESH]|Bone and Bones/anatomy & histology/*metabolism/*physiopathology[MESH]|Gonadal Hormones/metabolism[MESH]|Human Growth Hormone/metabolism[MESH]|Humans[MESH]|Hypothalamo-Hypophyseal System/*metabolism/*physiopathology[MESH]|Insulin-Like Growth Factor I/metabolism[MESH]|Thyroid Hormones/metabolism[MESH] |