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Iron-chelating therapy for transfusional iron overload Brittenham GMN Engl J Med 2011[Jan]; 364 (2): 146-56A 16-year-old boy with sickle cell anemia undergoes routine screening with transcranial Doppler ultrasonography to assess the risk of stroke. This examination shows an abnormally elevated blood-flow velocity in the middle cerebral artery. The hemoglobin level is 7.2 g per deciliter, the reticulocyte count is 12.5%, and the fetal hemoglobin level is 8.0%. Long-term treatment with red-cell transfusion is initiated to prevent stroke. A hematologist recommends prophylactic iron-chelating therapy.|*Chelation Therapy[MESH]|Adolescent[MESH]|Anemia, Sickle Cell/therapy[MESH]|Benzoates/therapeutic use[MESH]|Deferasirox[MESH]|Deferoxamine/therapeutic use[MESH]|Erythrocyte Transfusion/*adverse effects[MESH]|Humans[MESH]|Iron[MESH]|Iron Chelating Agents/administration & dosage/adverse effects/*therapeutic use[MESH]|Iron Overload/*drug therapy/etiology[MESH]|Male[MESH]|Practice Guidelines as Topic[MESH]|Triazoles/therapeutic use[MESH] |
