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TCR-engineered, customized, antitumor T cells for cancer immunotherapy: advantages and limitations Chhabra AScientificWorldJournal 2011[Jan]; 11 (ä): 121-9The clinical outcome of the traditional adoptive cancer immunotherapy approaches involving the administration of donor-derived immune effectors, expanded ex vivo, has not met expectations. This could be attributed, in part, to the lack of sufficient high-avidity antitumor T-cell precursors in most cancer patients, poor immunogenicity of cancer cells, and the technological limitations to generate a sufficiently large number of tumor antigen-specific T cells. In addition, the host immune regulatory mechanisms and immune homeostasis mechanisms, such as activation-induced cell death (AICD), could further limit the clinical efficacy of the adoptively administered antitumor T cells. Since generation of a sufficiently large number of potent antitumor immune effectors for adoptive administration is critical for the clinical success of this approach, recent advances towards generating customized donor-specific antitumor-effector T cells by engrafting human peripheral blood-derived T cells with a tumor-associated antigen-specific transgenic T-cell receptor (TCR) are quite interesting. This manuscript provides a brief overview of the TCR engineering-based cancer immunotherapy approach, its advantages, and the current limitations.|Humans[MESH]|Immunotherapy, Adoptive/*methods[MESH]|Neoplasms/*therapy[MESH]|Receptors, Antigen, T-Cell/genetics/*immunology/*metabolism[MESH]|T-Lymphocytes/*immunology/metabolism[MESH] |
