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Autosomal-dominant Alzheimer s disease: a review and proposal for the prevention of Alzheimer s disease Bateman RJ; Aisen PS; De Strooper B; Fox NC; Lemere CA; Ringman JM; Salloway S; Sperling RA; Windisch M; Xiong CAlzheimers Res Ther 2011[Jan]; 3 (1): 1Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.ä |
