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lüll The kidneys and aldosterone/mineralocorticoid receptor system in salt-sensitive hypertension Shibata S; Fujita TCurr Hypertens Rep 2011[Apr]; 13 (2): 109-15Strong evidence supports the ability of the aldosterone/mineralocorticoid receptor (MR) system to dominate long-term blood pressure control. It is also increasingly recognized as an important mediator of cardiovascular and renal diseases, particularly in the presence of excessive salt intake. In a subgroup of individuals with metabolic syndrome, adipocyte-derived aldosterone-releasing factors cause inappropriate secretion of aldosterone in the adrenal glands during salt loading, resulting in the development of salt-induced hypertension and cardiac and renal damage. On the other hand, emerging data reveal that aldosterone is not a sole regulator of MR activity. We have identified the signaling crosstalk between MR and small GTPase Rac1 as a novel pathway to facilitate MR signaling. Such a local control system for MR can also be relevant to the pathogenesis of salt-sensitive hypertension, and future studies will clarify the detailed mechanism for the intricate regulation of the aldosterone/MR cascade.|Aldosterone/*physiology[MESH]|Humans[MESH]|Hypertension/etiology/*physiopathology[MESH]|Kidney/*physiopathology[MESH]|Receptors, Mineralocorticoid[MESH]|Signal Transduction[MESH]|Sodium Chloride, Dietary/adverse effects[MESH] |