Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Rationale for inhibition of the hedgehog pathway paracrine loop in pancreatic adenocarcinoma Dimou A; Syrigos K; Saif MWJOP 2011[Jan]; 12 (1): 1-5The role of hedgehog pathway in the biology of pancreatic adenocarcinoma is an emerging area of investigation and provides a novel field for treatment intervention. Recent studies have shown the activation of the hedgehog pathway in pancreatic cancer. Despite the initial assumption of an autocrine mechanism, it seems that the hedgehog pathway contributes to the molecular conversation between tumor and its microenvironment through a paracrine loop. Furthermore, members of the hedgehog pathway crosstalk with other pathways; they regulate tumor angiogenesis and are associated with cancer stem cells. In addition, there is preclinical evidence about the efficiency of hedgehog inhibitors both in vitro and in vivo and the first clinical trials with those compounds in the treatment of patients with pancreatic adenocarcinoma, are already under way.|Adenocarcinoma/blood supply/drug therapy/*physiopathology[MESH]|Antineoplastic Agents/pharmacology/therapeutic use[MESH]|Hedgehog Proteins/*antagonists & inhibitors/physiology[MESH]|Humans[MESH]|Neovascularization, Pathologic/physiopathology[MESH]|Pancreatic Neoplasms/blood supply/drug therapy/*physiopathology[MESH]|Paracrine Communication/drug effects/*physiology[MESH]|Signal Transduction/physiology[MESH] |
