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Evolutionary crossroads in developmental biology: Dictyostelium discoideum Schaap PDevelopment 2011[Feb]; 138 (3): 387-96Dictyostelium discoideum belongs to a group of multicellular life forms that can also exist for long periods as single cells. This ability to shift between uni- and multicellularity makes the group ideal for studying the genetic changes that occurred at the crossroads between uni- and multicellular life. In this Primer, I discuss the mechanisms that control multicellular development in Dictyostelium discoideum and reconstruct how some of these mechanisms evolved from a stress response in the unicellular ancestor.|*Biological Evolution[MESH]|*Developmental Biology[MESH]|Dictyostelium/classification/cytology/*growth & development/*metabolism[MESH]|Models, Biological[MESH]|Phylogeny[MESH] |
