Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Has the microbiota played a critical role in the evolution of the adaptive immune system?Lee YK; Mazmanian SKScience 2010[Dec]; 330 (6012): 1768-73Although microbes have been classically viewed as pathogens, it is now well established that the majority of host-bacterial interactions are symbiotic. During development and into adulthood, gut bacteria shape the tissues, cells, and molecular profile of our gastrointestinal immune system. This partnership, forged over many millennia of coevolution, is based on a molecular exchange involving bacterial signals that are recognized by host receptors to mediate beneficial outcomes for both microbes and humans. We explore how specific aspects of the adaptive immune system are influenced by intestinal commensal bacteria. Understanding the molecular mechanisms that mediate symbiosis between commensal bacteria and humans may redefine how we view the evolution of adaptive immunity and consequently how we approach the treatment of numerous immunologic disorders.|*Adaptive Immunity[MESH]|*Bacterial Physiological Phenomena[MESH]|*Biological Evolution[MESH]|Animals[MESH]|Autoimmune Diseases/immunology[MESH]|Bacteria/immunology[MESH]|Cell Differentiation[MESH]|Humans[MESH]|Immune Tolerance[MESH]|Immunity, Innate[MESH]|Immunity, Mucosal[MESH]|Intestinal Mucosa/immunology/microbiology[MESH]|Intestines/immunology/*microbiology[MESH]|Metagenome/immunology/*physiology[MESH]|Symbiosis[MESH]|T-Lymphocytes, Helper-Inducer/cytology/immunology[MESH]|T-Lymphocytes, Regulatory/cytology/immunology[MESH] |
